Effect of the valved stent on closure of patent ductus arteriosus in a miniswine model
10.3760/cma.j.issn.0253-3758.2009.05.016
- VernacularTitle:带瓣膜心血管内支架封堵动脉导管未闭的可行性研究
- Author:
Yong-Xin ZHOU
1
;
Yong-Wu WANG
;
Jie SHAO
;
Lin SUN
;
Gang LI
;
Yun-Qing MEI
;
Dayi HU
Author Information
1. 同济大学附属同济医院
- Keywords:
Stents;
Ductus arteriosus,patent;
Heart valve prosthesis
- From:
Chinese Journal of Cardiology
2009;37(5):458-461
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the feasibility of a valved stent on closure patent ductus arteriosas in a Chinese miniswine model. Methods Self-expandable nitinol stents were made of Ni-Ti shape memory alloy (9 nun in diameter). Bovine pericardium was shaped and sutured onto the stents. Fluid passing test, pre-releasing test and static test of pressure in tube were performed in all devices before use. In eight Chinese miniswine, vascular grafts (PTFE vascular prosthesis) were surgically inserted between the descending thoracic aorta and pulmonary artery for establishment of patent duetus arteriasus model Valved stents were deployed to occlude the patent ductus arteriosus. Echocardiography was performed two hours post operation. Aortic angiography was made 30 days post operation in survived animals. Animals were then sacrificed for autopsy and electron microscopy examinations. Results In vitro testing showed that the closure of the valved stent leaflets was satisfactory and fluid flows were not restricted in the opposite direction. The valved stenta could be released through catheter, expanded completely, rapidly fixed in the tube. Closure of patent ductus arteriosas was succeeded in 6 out of 8 animals. One animal died of respiratory failure 2 hours post operation, another one died of pulmonary embolism due to valved stent displacement. Resident shunt was not evidenced by echocardiography, aortic angiography and dissection examinations in the remaining 6 animals. The new endothelial tissue fully covered the pulmonary and aortic sides of patent ductus arteriosus in 4 and 3 animals respectively. The electron microscopic observation revealed endothelial coverage of diveea. Conclusion The valved stent could effectively close artificial patent dactus arteriosus in vivo with satisfactory new intima covering on beth sides of patent ductus arteriosus.
