The effects of simvastatin on cardiac hypertrophy and association on calcium channel modulation in rats with myocardial hypertrophy induced by abdominal aortic constriction
10.3760/cma.j.issn.0253-3758.2009.04.015
- VernacularTitle:辛伐他汀对大鼠心肌肥厚的防治作用及其与钙通道的关系
- Author:
Yang WU
1
;
Hui-Chao YANG
;
Xiang CHEN
Author Information
1. 南通大学
- Keywords:
Cardiomegaly;
Calcium channels,T-Type;
Calcium channels,L-Type;
Simvastatin
- From:
Chinese Journal of Cardiology
2009;37(4):352-357
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of simvastatin(SIM)on cardiac hypertrophy and association with calcium channel modulation in rats with myocardial hypertrophy.Methods Myocardial hypertrophy was induced by abdominal aortic constriction(AAC)in adult SD rats.Following groups were studied(n=8 each):sham group,AAC group,AAC+verapamil group(10 mg·kg-1·d-3 per gavage for 4 weeks),AAC+SIM group(10 mg·kg-1·d-1 per gavage for 4 weeks)AAC+SIM+mevalonic acid (50 mg·kg-1·d-1 per gavage for 4 weeks)group.Systolic blood pressure(SBP),echocardiography,heart weight/body weight(HW/BW)and left ventricle weight/body weisht(LVW/BW)ratios were measured.The protein and mRNA expressions of L-type calcium channel subunit α1C and T-type calcium channel subunit α1 G and α1 H were detected by Western blot and RT-PCR respectively.Results SBP,HW/BW,LVW/BW,IVS and LVPW thickness,left ventricular weights were significantly increased in AAC rats and these effects could be significantly reduced by verapamil and SIM.The protein and mRNA expressions of α1G and α1H were significantly increased in AAC rats which could also be significantly inhibited by SIM or verapamil.The effects of SIM could be blocked by cotreatment with mevalonic acid.Protein and mRNA expressions of L-type calcium channel α1C were similar among groups.Conclusion Similar as verapamil,SIM could prevent AAC induced cardiac hypertrophy,possibly via inhibiting T-type calcium channel subunit α1 G and α1 H re-expression.
