Association of plasma amino-terminal pro-A-,B-and C-type natriuretic peptide levels with NYHA grade and echocardiographic derived parameters of cardiac function in heart failure patients
10.3760/cma.j.issn.0253-3758.2009.06.002
- VernacularTitle:心力衰竭患者N末端A、B及C型利钠肽原与超声心动图和心功能对比分析
- Author:
Xue-Yan ZHAO
1
;
Yue-Jin YANG
;
Jian ZHANG
;
Lian-Ming KANG
;
Ming LIAN
;
Bing-Qi WEI
;
Xiao-Jin GAO
;
Rong L(U)
;
Chun-Ling ZHANG
Author Information
1. 北京协和医学院中国医学科学院心血管病研究所阜外心血管病医院
- Keywords:
Heart failure,congestive;
Ventricular function,left;
Amino-terminal pro-A-type natriuretic peptide;
Amino-terminal pro-B-type natriuretic peptide: Amino-terminal pro-C-type natriuretic peptide
- From:
Chinese Journal of Cardiology
2009;37(6):486-490
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the correlation of plasma amino-terminal pro-A-,B-and C-type natriuretic peptide(NT-proANP,NT-proBNP and NT-proCNP)levels with New York Heart Association (NYHA)functional class and echocardiographic derived parameters of cardiac function in heart failure patients.Methods Data of NYHA grade,echocardiographic derived parameters of cardiac function,plasma levels of NT-proANP,NT-proBNP and NT-proCNP(measured by enzyme immunoassay method)were obtained in 112 heart failure patients and 44 normal control Subiects.The correlation analysis was made between NT-proANP,NT-proBNP,NT-proCNP and NYHA functional class,left atrium diameter(LAD),left ventricular end-diastolic diameter(LVEDD) and left ventricular ejection fraction(LVEF),respectively.Results The plasma concentrations of NT-proANP,NT-proBNP and NT-proCNP in heart failure patients were significantly higher than in control group(all P＜0.05).Correiation analysis revealed a strong correlation between NT-proANP and NT-proBNP(r=0.790,P=0.000)and a weak correlation between NT-proCNP and NT-proBNP(r=0.278,P=0.003)as well as between NT-proCNP and NT proANP(r=0.236,P=0.012)in heart failure patients.Univariant analysis showed that NT-proANP and NT-proBNP were positively correlated to LAD,LVEDD and negatively correlated to LVEF(all P＜0.05)while there was no significant correlation between NT-proCNP and echocardiographic derived parameters of cardiac function in heart failure patients.Multivariate stepwise regression analysis including age,gender,NYHA classification,LAD,LVEDD and LVEF revealed that NYHA classification,LVEF,LAD and age were independent predictors of NT-proANP;while NYHA classification,LVEF and age were independent predictors of NT-proBNP while there Was no association among these factors and NT-proCNP.Conclusion In heart failure patients,the plasma concentration of NT-proANP,NT-proBNP and NT-proCNP were significantly increased and NT-proANP,NT-proBNP but not NT-proCNP were significantly correlated to NYHA classification and echocardiographic derived parameters of cardiac function.
