Association between the number of peripheral blood stem cells and cardiac function index in patients with ischemic heart failure.
- Author:
Yu-ping ZHOU
1
;
Yuan-hui HU
;
Hua-qin WU
;
Cheng AN
;
Jie WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Cell Count; Female; Heart Failure; blood; physiopathology; Hematopoietic Stem Cells; cytology; Humans; Male; Middle Aged; Myocardial Ischemia; blood; physiopathology; Peptide Fragments; blood; Prognosis; Regression Analysis; Ventricular Dysfunction, Left
- From: Chinese Journal of Cardiology 2009;37(6):491-494
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the association between the number of peripheral blood stem cells (PBSC) and cardiac function index (NYHA grade, left ventricular ejection fraction, LVEF, N-terminal-proB-type Natriuretic Peptide, NT-pro BNP) in patients with ischemic heart failure (IHF).
METHODSA total of 199 patients hospitalized in our department between August 2007 and April 2008 due to IHF were included in this study. NYHA grade, LVEF (measured by echocardiography), plasma NT-proBNP and number of PBSC were analyzed.
RESULTSPBSC number was significantly decreased in proportion with increasing NYHA grade and PBSC number was significantly lower in patients with NYHA IV than that with class II and III (all P<0.01). LVEF was positively correlated with PBSC number (r = 0.35, P = 0.001), NT-proBNP was negatively correlated with PBSC number (r = - 0.39, P = 0.009). Multiple regression analysis showed that LVEF and NT-proBNP were major determinants of PBSC (Beta = 0.14, - 0.25, 95% CI = -0.01 - 0.02, -0.18 - -0.04, P<0.05, P<0.01).
CONCLUSIONPBSC number was significantly correlated to cardiac function in IHF patients.
