Association between hemoglobin scavenger receptor CD163 expression and coronary atherosclerotic severity in patients with coronary heart disease
10.3760/cma.j.issn.0253-3758.2009.07.009
- VernacularTitle:血红蛋白清道夫受体在冠心病患者中的表达及其与冠状动脉病变的关系
- Author:
Li-Yuan ZOU
1
;
Chao-Quan PENG
;
Cui-Zhi LI
;
Chang-Lin ZHAO
;
Jie-Ming ZHU
;
Jin-Lai LIU
;
Cheng-Xi ZHANG
Author Information
1. 中山大学附属第三医院
- Keywords:
Coronary disease;
Receptors,scavenger;
Inflammation
- From:
Chinese Journal of Cardiology
2009;37(7):605-609
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between hemoglobin scavenger receptor (CD163) expression levels on monocytic surfaces and coronary atheresclerotic severity in patients with coronary heart disease (CHD) as well as the roles of CD163 in inflammation and lipidperoxidation.Methods Eighty-four patients were diagnosed as CHD according to the results of coronary angiography and ACC/AHA diagnostic criteria.The patients were divided into 3 groups : acute myocardial infarction (AMI) group (n=30),unstable angina (UA) group (n=30),stable angina (SA) group (n=24).Another 20 patients with normal coronary artery served as control.Expression levels of CD163 on monocytes were detected by means of flow cytometry,and the results were shown as mean fluorescence intensity (mfi).All patients underwent coronary angiography and the results were further evaluated by Jenkins score.Serum CRP and LDL-C were also measured.Results The expression levels of CD163 on monocytes in peripheral blood were significantly higher in CHD patients compared to controls (P < 0.01) in the order of AMI group [(84.4±6.9)mfi] > UA group [(64.1 ±5.5)mfi,P<0.01 vs.AMI] > SA group [(46.7±6.5)mfi,P < 0.01 vs.AMI and UA] > control group [(22.0 ± 6.1) mfi,P < 0.01 vs.AMI,UA and SA].The expression levels of CD163 on monocytes in patients with CHD were positively correlated with Jenkins score (r=0.9107,P<0.01),CRP(r =0.766,P<0.01)and LDL-C(r =0.749,P<0.01).Conclusions Expression levels of CD163 was significantly increased in patients with CHD and positively correlated with coronary heart disease severity and serum CRP and LDL-C.
