Association of trytophan hydroxylase gone A218C and serotonin transporter gone polymorphism with essential hypertension in Chinese northern Hart population
10.3760/cma.j.issn.0253-3758.2009.07.010
- VernacularTitle:色氨酸羟化酶基因A218C及5-羟色胺转运体基因多态性与原发性高血压
- Author:
Da-Sheng XIA
1
;
Cheng-Zhi LU
;
Qian-Yu GUO
;
Yan-Qiu SONG
;
Chao LI
;
Jian-Qiang XU
;
Feng ZHANG
Author Information
1. 天津市第一中心医院
- Keywords:
Hypertension;
Polymorphism,single nucleotide;
Serotonin plasma membrane transport proteins
- From:
Chinese Journal of Cardiology
2009;37(7):610-614
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between trytophan hydroxylase (TPH) gene A218C in intren 7 and 5-hydroxytryptamine transporter (5-HTT) gene variable number tandem repeat (VNTR) in intron 2 and gene-linked polymorphic region (LPR) deletion/iusertion polymorphism and essential hypertension (EH) in Chinese northern Han population.Methods A total of 280 EH patients and 200 normoteusive controls were genotyped using polymerase chain reaction-restriction fragment length polymorphism technique.Results There were no significant differences in the frequencies of the genotypes and alleles of TPH gene A218C and 5-HTTVNTR between EH patents and controls (all P > 0.05).The genotype frequencies of SS,LS and LL in the 5-HTTLPR polymorphism was 68%,29% and 3% in EH patients,53% ,37% and 10% in the controls respectively (P <0.01).The frequencies of allele S and L of the 5-HTTLPR were 82% and 18% in EH patients,72% and 28% in the controls respectively (P < 0.01).Compared with the carriers of L allele (LS + LL),the EH risk was significantly higher in the SS hmnozygote (OR = 1.90,95 % CI = 1.31 - 2.77,P = 0.001).After adjustment of age,gender,body mass index,blood lipids,fasting blood glucose and blood uric acid level,the binary logistic regression analysis demonstrated that SS genotype in the 5-HTTLPR polymorphism was significantly related to occurrence of EH (OR = 1.47,95%CI=1.06-2.04,P=0.021).Conclusions The SS genotype Of the 5-HTTLPR might be a susceptible gene to EH,while the TPH gene A218C and 5-HTrVNTR polymorphism is not associated with EH in Chinese northern Han population.
