Effects of perindopril and spirolactone on plasma aldosterone and left atrial remodeling in a canine model of atrial fibrillation
10.3760/cma.j.issn.0253-3758.2009.07.015
- VernacularTitle:醛固酮及心房间质重构与心房颤动关系的实验研究
- Author:
Tai-Yang LUO
1
;
Xiao-Hui LIU
;
Xin DU
;
Xing-Peng LIU
;
Tao LEI
;
Hai-Yun WANG
;
Jia-Hai SHI
Author Information
1. 首都医科大学附属北京安贞医院
- Keywords:
Atrial fibrillation;
Aldosterone;
Heart atrium;
Fibrosis
- From:
Chinese Journal of Cardiology
2009;37(7):626-629
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of perindopril and spirolactone on plasma aldosterone (Ald) and left atrial remodeling and function in a canine model of atrial fibrillation (AF).Methods Adult dogs were randomly assigned to receive normal diet (group A),perindopril (group B,1 mg· kg-1 · d-1) and spironolactone (group C,10 mg · kg-1 ·d-1,n=6 each) and rapid paced (500 beats/min) for 8 weeks.Plasma Ald levels as well as atrial dimension and function at baseline and at 4 and 8 weeks after pacing were measured by RIA and echocardiography,respectively.Incidence of maintained AF and AF duration were recorded when pacing was stopped after 8 weeks of pacing.Left and right atrial tissues were collected for measurements of tissue Aid levels and fibrosis.Results Plasma Ald was similar among groups at baseline (P > 0.05) and significantly increased post 4 and 8 weeks pacing in group A (P < 0.05) while remained unchanged post pacing in group B and C (P >0.05) compared to respective baseline level.Atrial Ald was significantly rower in group B and C compared that in group A post 8 weeks pacing (P < 0.05).Left atrial dimension,end-systolic and end-diastolic volume were significantly increased while left atrial ejection fraction (LAEF) was significantly reduced post pacing in group A (all P <0.05 vs.baseline) and thses changes were significantly attenuated in group B and C (P < 0.05 vs.group A).Incidence of maintained AF and AF duration post pacing as well as interstitial collagen volume fraction were significantly lower in group B and C compared those in group A (P < 0.05).Conclusion Increased Ald might be an important pathogenesis for AF formation and progression,spironolactone and perindopril could attenuate atrial remodeling and improve atrial function by reducing plasma and tissue Aid levels in this model.
