Association and interaction between the components of metabolic syndrome and cardiovascular disease
10.3760/cma.j.issn.0253-3758.2009.07.019
- VernacularTitle:代谢综合征与心血管疾病的关系及其组分间的交互作用
- Author:
Lu GUO
1
;
Xiao-Shu HU
;
Zhi-Rong GUO
;
Guo-Dong KANG
;
Ming WU
;
Hui ZHOU
Author Information
1. 苏州大学医学部
- Keywords:
Metabolic syndrome X;
Cardiovascular disease;
Cohort studies
- From:
Chinese Journal of Cardiology
2009;37(7):644-647
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association and interaction between the components of metabolic syndrome (MS) and cardiovascular disease (CVD).Method In this cohort study,participants (total 3598,male 1451) were recruited and followed up for five years from the program "prevention of multiple metabolic disorders and MS in Jiangsu province".We used modified Asian criteria of the National Cholesterol Education Program Adult Treatment Panel Ⅲ (NCEP ATP Ⅲ) to define the presence of MS.COX regression was used to analyze the association between the MS and its components with CVD; both the multiplication of blood pressure (BP) and 2,3 ,or 4 other components of MS in the logistic regression model and the estimation of the relative excess risk due to interaction (RERI),the attributable proportion due to interaction (AP),and the synergy index (S) and 95% confidence intervals (95%CI) were used to evaluate the interactions between the components of MS.Results After adjustment for traditional CVD risks,the adjusted risk ratio (αRR) of CVD was 2.49 (95% CI: 1.59-3.90) in the MS group compared with the non-MS group at baseline.The αRRs of MS components to CVD were as follows: 1.44 (95% C1:0.88-2.37) for waist circumfcrence; 2.84 (95% CI:1.73-4.68) for BP; 1.31 (95 % CI:0.83-2.07) for low high density lipoprotein; 1.84 (95 % CI: 1.19-2.85) for triglyceride; 1.55 (95 % CI: 0.98 -2.45) for fasting plasma glucose,respectively.BP was the single component significantly related to CVD (αRR =2.58,95% CI: 1.55 -4.29).The risk of CVD was significantly increased (αOR = 4.47,95 % CI: 2.35 -8.51) when BP was combined with 2,3 or 4 other components of MS in the participants.Conclusions Only BP is an independent CVD risk factor in the components of MS,the risk of CVD was significantly increased when BP was combined with other components of MS in this cohort.
