Effect of tirofiban in acute anterior myocardial infarction patients without ST segment resolution after primary percutaneous coronary intervention
10.3760/cma.j.issn.0253-3758.2009.08.013
- VernacularTitle:替罗非班对急诊冠状动脉介入治疗后ST段回落不良的急性前壁心肌梗死患者预后的影响
- Author:
Jian-Jun PENG
1
;
Zhi-Min MA
;
Lihui REN
;
Gui-Qin FU
;
Kai-Ying JIA
;
Li-Cheng LEI
;
Hui-Ming YE
Author Information
1. 北京市世纪坛医院
- Keywords:
Myocardial infarction;
Angioplasty,transluminal,percutaneous coronary;
Prognosis
- From:
Chinese Journal of Cardiology
2009;37(8):725-728
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of glycoprotein receptor blockade tirofiban in acute anterior myocardial infarction patients without ST segment resolution after primary percutaneous coronary intervention (PCI). Methods From April 2006 to April 2008, 157 acute anterior myocardial infarction patients without ST segment resolution after PCI were randomly allocated to tirofiban (intravenous bolus 10 fig/kg followed by intravenous infusion of 0. 15 μg·kg-1·min-1 for 48 h, n =80) or equal volume saline (control group, n =77). Baseline characteristics, PCI features and clinical outcomes during hospitalization, left ventricular ejection fractions (LVEF) and major adverse cardiac events (MACE, including death, re-infarction and target vessel revascularization) at 30 and 180 days after discharge were compared between the two groups. Results The baseline clinical characteristics were comparable between the two groups. Compared to control group, the MACE rates and re-infarction rates at 30 days (6. 3% vs. 18. 2% , P < 0.05; 1.3% vs. 9. 1%, P<0.05, respectively) and 180 days (10.0% vs. 23. 4% , P<0.05; 2.5% vs. 10.4% , P < 0. 05, respectively ) were significantly reduced in tirofiban group. LVEF value was significantly higher in tirofiban group at 30 days and 180 days compared with those in control group [ (51 ± 6)% vs. (46±8)%, P<0.05; (57±7)% vs. (50±9)%, P<0.05]. Hemorrhagic complications were similar between the two groups. Conclusion Use of tirofiban for acute anterior myocardial infarction patients without ST segment resolution after PCI is safe and can significantly improve 30 and 180 days clinical outcomes after discharge.
