Application of HLAMatchmaker analysis eplets mismatch of renal transplant matching.
- Author:
Xing ZHANG
;
Xiao-Dong PAN
;
Hui-Ying XU
;
Cun-Zao WU
;
Yong CAI
;
Peng XIA
;
Shao-Ling ZHENG
;
Yi-Rong YANG
;
Bi-Cheng CHEN
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Female; Histocompatibility Testing; methods; Humans; Kidney Transplantation; Male; Middle Aged; Software; Transplantation, Homologous; Young Adult
- From: Chinese Journal of Applied Physiology 2014;30(3):237-241
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEEplets mismatch based on HLAMatchmaker software evaluates the clinical application of kidney transplantation.
METHODSIn 239 cases of renal transplant,merits of methods of the traditional HLA six antigen matcheing criteria, cross reaction groups standard and Eplets mismatch based on HLAMatchmaker standard were compared respectively.
RESULTSThe number of mismatchs with three methods in 239 cases, were grouped according to low-high mismatchs. The results revealed that HLAMatchmaker algorithm could significantly increase the number of low mismatchs group 54 (22.6%), compared with the HIA group 19(7.9%) and CREGs group 32 (13.4%). The comparison was discovered statistical significance among the three groups (P<0.001), so the comparison between each group was.
CONCLUSIONHLAMachmaker of donor-recipients matching, is a more efficient, time-saving and high sensitivity matching solution to allograft renal transplantation.