Effect of Shugan Jianpi Granule () on gut mucosal serotonin-positive cells in patients with irritable bowel syndrome of stagnated Gan-qi attacking Pi syndrome type.
- Author:
Zai-jian WANG
1
;
Hui-xia LI
;
Jing-hua WANG
;
Fan ZHANG
Author Information
- Publication Type:Clinical Trial
- MeSH: Adult; Cell Count; Drugs, Chinese Herbal; pharmacology; therapeutic use; Female; Humans; Immunohistochemistry; Intestinal Mucosa; drug effects; pathology; Irritable Bowel Syndrome; drug therapy; pathology; Male; Medicine, Chinese Traditional; Middle Aged; Phytotherapy; Serotonin; metabolism; Syndrome
- From: Chinese journal of integrative medicine 2008;14(3):185-189
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo evaluate the effect of Shugan Jianpi Granule (, SJG) on the number of gut mucosal serotonin-positive cells (5-HT+C) in patients with irritable bowel syndrome (IBS) of stagnated Gan-qi attacking Pi (SGAP) syndrome type.
METHODSTwenty-four patients were randomized equally into three groups. All were treated with the basic conventional treatment by cognition-behavior therapy with assistance of lactein 3 tablets thrice a day. Additionally, 24 g of SJG was given three times a day to group A, and the same dosage of SJG and Smecta 15 g thrice a day was given to group B, while no additional treatment was given to the control group. The number of 5-HT+C was measured respectively before and two weeks after treatment by immunohistochemical method.
RESULTSThe number of 5-HT+C decreased after treatment in all the three groups (P<0.05), but the decrement was more significant in the two test groups than in the control group (P<0.05 and P<0.01, respectively), while comparison of 5-HT+C between the two test groups showed insignificant difference (P>0.05).
CONCLUSIONSJG can reduce the number of 5-HT+C in IBS patients of SGAP syndrome type, and its effect is enhanced when used in combination with Smecta.
