Evaluation for preparation and anticancer efficacy in vitro of drug-loaded nanoerythrosomes.
- Author:
Qian-Feng CHENG
1
;
Han-Qing QIAN
1
;
Ding-Hu ZHANG
1
;
Ying HUANG
1
;
Hui-Zi SHA
1
;
Bao-Rui LIU
1
Author Information
- Publication Type:Journal Article
- Keywords: anti-tumor; curumin; erythrocyte membrane; erythrocytes; nanoparticles
- From: China Journal of Chinese Materia Medica 2016;41(11):2093-2097
- CountryChina
- Language:Chinese
- Abstract: The objective of this study is to develop a new-type biodegradable, biocompatible curcumin-loaded nanoerythrosomes (Cur-RBC-NPs) by means of the sonication method. The size of Cur-RBC-NPs was optimized by varying drug loading parameters. The morphology, size distribution, stability, in vitro release pattern, cellular uptake of nanoparticles and in vitro anti-tumor effects were evaluated, respectively. The results showed the prepared Cur-RBC-NPs were nearly uniform spheres, with an average diameter of (245.7 ± 1.3) nm. Encapsulation efficiency (EE) and load efficiency (LE) of Cur-RBC-NPs were 50.65% ± 1.36% and 6.27% ± 0.29%. And the nanoparticles had a good sustained release property. According to the in vitro experiment, Cur-RBC-NPs were effectively taken in by tumor cells, and exhibited a significant anti-tumor effect. In conclusion, the method for preparing Cur-RBC-NPs is convenient, with a good sustained release behavior and anti-tumor efficacy, and so expected to be a new-type nano-drug delivery system in clinical practice.
