Analysis of influencing factors on adverse reaction of Shengfu injection based on prospective active safety monitoring.
- Author:
Zhi-fei WANG
;
Wei ZHAO
;
Yin ZHANG
;
Yan-ming XIE
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Drug Hypersensitivity;
etiology;
Drugs, Chinese Herbal;
adverse effects;
Female;
Humans;
Injections;
Male;
Middle Aged;
Prospective Studies
- From:
China Journal of Chinese Materia Medica
2015;40(24):4746-4751
- CountryChina
- Language:Chinese
-
Abstract:
This study collected demographic data, past history, personal history, family history, dosage, solvent, combined medication information of adverse reaction cases from a prospective, multi center, large sample intensive hospital monitoring, and found the influencing factors with cross-tab analysis. The results showed that in the medication group of 19-45, patients with allergic histories had a higher proportion in ADR; in the medication group of 46-65, male patients with allergic histories had a higher proportion in ADR; indication and non-indication group, patients of 19-45 years old, with combined medications and allergy histories had a higher proportion in ADR; Non-indication medication group, patients with combined medication, higher concentration, out-instruction solvent and dosage, had a higher proportion in ADR. So, the ADRs of Shenfu injection were related to the history of drug allergy, and also related to the indication, dosage, solvent, concentration when it was used.
