Recent advances in natural product induced DNA damage response in cancer cells.
- Author:
Guo-wen REN
;
Ya-nan NIU
;
Jin-jian LU
;
Yi-tao WANG
;
Xiu-ping CHEN
- Publication Type:Journal Article
- MeSH:
Animals;
Biological Products;
pharmacology;
therapeutic use;
DNA Damage;
Drugs, Chinese Herbal;
therapeutic use;
Humans;
Neoplasms;
drug therapy
- From:
China Journal of Chinese Materia Medica
2015;40(24):4797-4804
- CountryChina
- Language:Chinese
-
Abstract:
The DNA structures could be altered or even damaged by exogeous or endogenous factors during cell proliferation. Failure of effective and timely repair will lead to cell cycle arrest or apoptosis. By taking the advantage of the quick proliferation of cancer cells, DNA damage induction, cell cycle arrest and apoptosis promotion have become important strategies for ant-cancer chemotherapy. Previous reports showed that an array of natural compounds inhibit cancer cell proliferation by inducing DNA damage, which have therapeutic potentials for anti-cancer drug research and development.
