Chemical constituents from Barringtonia racemosa.

Huan Xia; Xi-long Zhang; Guo-hua Wang; Yong-chun Tong; Lei HE; Hai-feng Wang; Yue-hu Pei; Yan-jun Chen; Yi Sun

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Chemical constituents from Barringtonia racemosa.

Author: Huan XIA ¹ ; Xi-Long ZHANG ² ; Guo-Hua WANG ¹ ; Yong-Chun TONG ¹ ; Lei HE ¹ ; Hai-Feng WANG ³ ; Yue-Hu PEI ³ ; Yan-Jun CHEN ¹ ; Yi SUN ¹
Author Information

1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
2. Hainan Branch Institute of Medical Plant Development, Chinese Academy of Medical Sciences, Wanning 571100, China.
3. College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
Publication Type:Journal Article
Keywords: Barringtonia racemosa; chemical constituents; cytotoxicity; triterpenes
From: China Journal of Chinese Materia Medica 2016;41(13):2460-2465
CountryChina
Language:Chinese
Abstract: To investigate the chemical constituents from Barringtonia racemosa, twelve compounds were isolated by chromatography methods and identified as 3β-p-E-coumaroymaslinic acid (1), cis-careaborin (2), careaborin (3), maslinic acid (4), 2α, 3β, 19α-trihydroxyolean-12-ene-24, 28-dioic acid (5), 3β-p-Z-coumaroylcorosolic acid (6), corosolic acid (7), 1α, 2α, 3β, 19α-tetrahydroxyurs-12-en-28-oic acid (8), 19α-hydroxyl ursolic acid (9), 3α, 19α-dihydroxyurs-12-en-24, 28-dioic acid (10), tormentic acid (11), 3-hydroxy-7, 22-dien-ergosterol（12） by the NMR and MS data analysis. Among them, compounds 1-4,7-12 were obtained from the genus Barringtonia for the first time. All the compounds didn't show nocytotoxic activity against MCF-7 and A549 cell lines (IC₅₀>50 mg•L⁻¹).