Association between chemical composition of essential oil with penetration enhancement effect and drug properties of traditional Chinese medicine.
- Author:
Qiu-Dong JIANG
1
;
Wen-Guo YANG
2
;
Hao CAI
3
;
Min MA
1
;
Hui ZHANG
1
;
Pei LIU
1
;
Jun CHEN
1
;
Jin-Ao DUAN
1
Author Information
- Publication Type:Journal Article
- Keywords: Logistic regression analysis; chemical composition; drug properties of traditional Chinese medicine; essential oil; transdermal penetration
- From: China Journal of Chinese Materia Medica 2016;41(13):2500-2505
- CountryChina
- Language:Chinese
- Abstract: The results of previous studies showed potential correlations between the penetration enhancement effect of essential oils and the drug properties of traditional Chinese medicine based on the data mining method. As chemical composition is the material basis of drug properties of traditional Chinese medicine, this article further analyzed the correlation between the chemical composition of essential oils and the drug properties. Firstly, essential oils were extracted by steam distillation, and then physicochemical parameters of essential oils, such as relative density and refractive index, were measured. The chemical components of 20 essential oils were analyzed by GC-MS, and divided into 12 categories according to skeleton features and functional groups. Finally, Logistic regression analysis was applied to reveal the correlations. The results proved that five flavors, four tastes and channel tropisms showed the correlation with chemical composition of essential oils (P<0.05). In conclusion, there were obvious correlations and regularity between the drug properties of traditional Chinese medicine and the chemical composition of essential oils.
