Expression of TGF-beta receptors in CD8+ T cells of oral lichen planus.
- Author:
Lei LEI
1
;
Miao YU
;
Xin-Yu GAO
;
Xu-Long ZHOU
;
Li-Hua ZHAN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; CD8-Positive T-Lymphocytes; metabolism; Case-Control Studies; Female; Humans; Lichen Planus, Oral; metabolism; pathology; Male; Mouth Mucosa; metabolism; pathology; Protein-Serine-Threonine Kinases; metabolism; Receptors, Transforming Growth Factor beta; metabolism; Signal Transduction
- From: Chinese Journal of Stomatology 2008;43(2):99-100
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of TGF-beta receptors in CD8+ T cells of oral lichen planus (OLP).
METHODSImmunohistochemical double labeling technique was used to examine the expression of TGF-betaR I and TGF-betaR II in CD8+ T cells of 28 OLP patients and in 10 controls. The results were compared between the two groups.
RESULTSThe double labeled cells were negative in controls. The positive rates of double labeled cells of CD8+/TGF-betaR I and CD8+/TGF-betaR II in OLP were (8.82 +/- 9.98)% and (1.11 +/- 2.94)% respectively.
CONCLUSIONSThe expression level of TGF-betaR II in CD8+ T cells of OLP did not increase compared with the controls, but the expression of TGF-betaR I increased. The results indicate the abnormal TGF-beta signal transduction in CD8+ T cells of OLP, which may contribute to the persistence of the chronic inflammation in OLP.
