Application of bioinformatics tools in analysis of differentially expressed genes in oral submucosal fibrosis
10.3321/j.issn:1002-0098.2008.03.012
- VernacularTitle:两种基因芯片数据分析软件在口腔黏膜下纤维化差异表达基因分析中的应用
- Author:
Yan-Jia HU
1
;
Xin-Chun JIAN
;
Bin-Jie LIU
;
Jie-Ying PENG
Author Information
1. 中南大学湘雅医院
- Keywords:
Oral submucous fibrosis;
Computation biology;
Genes
- From:
Chinese Journal of Stomatology
2008;43(3):168-171
- CountryChina
- Language:Chinese
-
Abstract:
Objective To apply the bioinformatics tools for analyzing the differentially expressed genes in oral submucous fibrosis(OSF)to obtain the implied biological significance.Methods By using DAVID and Onto-express bioinformatic tools.865 differentially expressed genes in OSF were analized and the analysis of chromosome location,gene ontology(GO)and genetic-association diseases were performed.Results A majority of the differentially expressed genes were located on chromosome 1,2,5,6,7,11,12(P＜0.01).GO classification of the differentially expressed genes identified the biological process subgroups,including genes involved in immune response,defense response and so on.The cellular component subgroups were associated with extracellular matrix,cytoskeleton and membrane,molecular function subgroups related to protein binding,extracellular matrix structural constituent and signal transducer activity.The diseases genetically associated with these genes included infection.immune and cardiovascular diseases.Conclusions Bioinformatics can provide the quick and parallel analysis of massive data got from gene microarrays and enable the function classification of the differentially expressed genes,which provides new ideas on the research of pathogenesis and epidemiology of OSF.
