The relativity between chronic periodontitis and the genetic polymorphisms of vitamin D receptor and estrogen receptor
10.3321/j.issn:1002-0098.2008.04.017
- VernacularTitle:维生素D受体和雌激素受体基因多态性与慢性牙周炎的相关性
- Author:
Hong-Yan WANG
1
;
Ya-Ping PAN
;
Di TENG
;
Jian ZHAO
;
Li LIN
Author Information
1. 中国医科大学口腔医学院
- Keywords:
Periodontitis;
Receptors,calcitriol;
Receptors,estrogen;
Genetic polymorphism
- From:
Chinese Journal of Stomatology
2008;43(4):236-239
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between chronic periodontitis and the genetic polymorphisms of vitamin D receptor gene and estrogen receptor gene.Methods Clinical parameters including probing depth,clinical attachment loss,sulcus bleeding index and tooth movement were measured by floride probe.Genomic DNA from peripheral venous blood was extracted with saturant sodium chloride,and PCR-restriction fragment length polymorphism was applied to examine the Apa Ⅰ,Bsm Ⅰ,Taq Ⅰpolymorphisms of the vitamin D receptor genes and the Xba Ⅰ and PvuⅡpolymorphisms of the estrogen receptor genes.The results were analyzed by Z-score test and mean square analysis.Results Forty-three point four percent of chronic periodontitis patients took vitamin D receptor BB genotype,the rate in healthy controls was 30.0%.39.6% of chronic periodontitis patients took estrogen receptor XX genotype,the rate in healthy controls was 20.0%.The people who took BBXX genotype had the worst periodontal conditions among all chronic periodontitis patients.Conclusions Vitamin D receptor allele B and estrogen receptor allele X ale susceptible alleles for chronic periodontitis.The synergistic effects of the two receptor susceptible alleles may promote chronic periodontitis.
