Effect of cryopreservation of bone marrow stromal cells on periodontal tissue regeneration.
- Author:
Hou-Xuan LI
1
;
Fu-Hu YAN
;
Lang LEI
;
Jian-Guo LIU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Bone Marrow Cells; cytology; Bone Marrow Transplantation; methods; Cryopreservation; Dogs; Female; Guided Tissue Regeneration, Periodontal; Periodontal Diseases; surgery; Transplantation, Autologous
- From: Chinese Journal of Stomatology 2008;43(4):246-247
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the influence of cryopreservation on bone marrow stromal cells' (BMSC) capability of enhancing periodontal regeneration.
METHODSTwenty-six artificial periodontal defects were established in 5 Beagle dogs and divided into 3 groups at random. Only collagen membrane, the complex of cryopreserved and un-cryopreserved BMSC and collagen scaffold were transplanted in the blank control group, cryopreserved and un-cryopreserved groups respectively. The periodontal regeneration was observed 8 weeks after transplantation.
RESULTSThe percentage of periodontal regeneration in cryopreserved and un-cryopreserved groups was significantly greater than that of the blank control group (P < 0.05), but no statistical difference was found between cryopreserved and un-cryopreserved groups.
CONCLUSIONSCryopreservation had no significant negative effects on BMSC capability of enhancing periodontal regeneration.
