Effect of cryopreservation of bone marrow stromal cells on periodontal tissue regeneration
10.3321/j.issn:1002-0098.2008.04.020
- VernacularTitle:自体移植冻存骨髓基质细胞修复犬牙周缺损的实验
- Author:
Hou-Xuan LI
1
;
Fu-Hua YAN
;
Lang LEI
;
Jian-Guo LIU
Author Information
1. 福建医科大学口腔医学院
- Keywords:
Cryopreservation;
Guided tissue regeneration,periodontal;
Bone marrow stromal ceils
- From:
Chinese Journal of Stomatology
2008;43(4):246-247
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of cryopreservation on bone marrow stromal cells'(BMSC)capability of enhancing periodontal regeneration.Methods Twenty-six artificial periodontal defects were established in 5 Beagle dogs and divided into 3 groups at random.Only collagen membrane,the complex of cryopreserved and uncryopreserved BMSC and collagen scaffold were transplanted in the blank control group,cropreserved and uncryopreserved groups respectively.The periodontal regeneration was observed 8 weeks after transplantation.Results The percentage of periodontal regeneration in cryopreserved and uncryopreserved groups was significantly greater than that of the blank control group(P<0.05),but no statistical difierence was found between cryopreserved and uncryopreserved groups.Conclusions Cryopreservation had no significant negative effects on BMSC capability of enhancing periodontal regeneration.
