Effects of lactational dioxin exposure to development of alveolar bone in SD rat offspring

VernacularTitle:鼠哺乳期二(噁)英暴露对子代牙槽骨生长发育的影响
Author: Hua-Ou GENG ¹ ; Jin-Cai ZHANG ; Bin HU ; Jing-Bin WANG
Author Information

1. 广东省口腔医院
Keywords: Tetrachlorodibenzodioxin; Environmental exposure; Alveolar bone loss; Bone histomorphometry
From: Chinese Journal of Stomatology 2008;43(5):278-280
CountryChina
Language:Chinese
Abstract: Objective To study the influence of lactational dioxin exposure(2,3,7,8-tetrachlorodibenzo-p-dixon,TCDD)on development of alveolar bone in SD rat offspring.Methods The rats of TCDD exposure group and control group were sacrificed and the alveolar bone with molars of PD60 rats in the two groups were embedded in resin.The sections were observed by fluorescent microscope.The alveolar bone formation was evaluated by histological examination,tetracycline fluorescence marker and quantitative histomorphometry.The indices of quantitative histomorphometry were compaired.Resuits The trabecular structure of abeolar bone was looser in TCDD exposure group than in the control group.The tetracycline fluorescence markers were more disorganized in TCDD group.The indices of quantitative histomorphometry of alveolar bone between two groups showed significantly difierent. Conclusions Lactational 2,3,7,8-TCDD exposure decreased the quality and quantity of alveolar bone in SD rat offspring.It is suggested that dioxins exposure may interrupt the spatial configuration.