Effect of micronized fenofibrate on vascular endothelial function in patients with hypertriglyceridemia.
- Author:
Yun HUANG
1
;
Guizhu DAI
;
Zongchen FENG
;
Chengfa LU
;
Bei CHENG
;
Qiufen WANG
;
Fuding NIE
;
Jingdong LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Endothelium, Vascular; drug effects; physiology; Female; Fenofibrate; pharmacology; therapeutic use; Humans; Hypertriglyceridemia; drug therapy; Male; Middle Aged; Vasodilation; drug effects
- From: Chinese Medical Journal 2003;116(11):1767-1769
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo investigate the effect of micronized fenofibrate on vascular endothelial function in patients with hypertriglyceridemia.
METHODSUsing high-resolution ultrasound, we measured flow- and nitroglycerin-induced dilatation of the brachial artery in 30 patients with hypertriglyceridemia before and after treatment with micronized fenofibrate at a dose of 200 mg once daily for 4 weeks. Simultaneously, both serum lipid and plasma endothelin (ET) levels were determined.
RESULTSAfter micronized fenofibrate therapy, serum triglyceride (TG) levels decreased significantly (P < 0.05). Plasma ET levels also decreased markedly [(82.66 +/- 15.46) microg/L vs. (106.22 +/- 19.16) microg/L, P < 0.001]. Flow-induced vasodilatation was much improved (11.0% +/- 9.0% vs 2.7% +/- 2.0%, P < 0.01). However, no significant changes in vasodilatation occurred in response to nitroglycerin (16.2% +/- 6.0% vs 15.0% +/- 5.0%, P > 0.05) in patients with hypertriglyceridemia.
CONCLUSIONSMicronized fenofibrate can improve impaired endothelium-dependent vasodilatation in patients with hypertriglyceridemia. Improving endothelial function may also be the mechanism responsible for the beneficial effects of micronized fenofibrate.
