Expression of hypoxia-inducible factor 1alpha in human normal, benign, and malignant prostate tissue.
- Author:
Zhenxian DU
1
;
Chisato FUJIYAMA
;
Yongxin CHEN
;
Zenjiro MASAKI
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Aged, 80 and over; DNA-Binding Proteins; analysis; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Male; Middle Aged; Nuclear Proteins; analysis; Prostate; chemistry; Prostatic Hyperplasia; metabolism; Prostatic Neoplasms; chemistry; Transcription Factors
- From: Chinese Medical Journal 2003;116(12):1936-1939
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo investigate hypoxia-inducible factor 1alpha (HIF-1alpha) protein expression in normal prostates (NP), benign prostatic glandular hyperplasia (BPH), and prostate adenocarcinoma (Pca).
METHODSHIF-1alpha protein expression was determined by immunohistochemistry in formalin-fixed and paraffin-embedded specimens obtained from 13 cases of NP, 28 cases of BPH, and 34 cases of Pca. In cases of Pca, the relationship between HIF-1alpha protein expression and certain clinicopathological factors, such as clinicopathologic stage and Gleason score, was evaluated.
RESULTSNP manifested no immunoreactivity, whereas Pca and BPH showed significantly increased HIF-1alpha protein expression. A significantly higher expression was observed in Pca specimens compared with BPH samples. In Pca, no significant relationship between HIF-1alpha protein expression and clinicopathological factors was found.
CONCLUSIONOur findings of increased HIF-1alpha protein expression in BPH and Pca specimens suggests the potential role of this protein in BPH and Pca.
