Superselective uterine arterial embolization with pingyangmycin-lipiodol emulsion for management of symptomatic uterine leiomyoma.
- Author:
Hong SHAN
1
;
Ming-sheng HUANG
;
Shou-hai GUAN
;
Zai-bo JIANG
;
Kang-shun ZHU
;
Zheng-ran LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Antibiotics, Antineoplastic; administration & dosage; Bleomycin; administration & dosage; analogs & derivatives; Contrast Media; administration & dosage; Embolization, Therapeutic; methods; Emulsions; Female; Follow-Up Studies; Humans; Iodized Oil; administration & dosage; Leiomyoma; therapy; Middle Aged; Uterine Neoplasms; therapy; Uterus; blood supply
- From: Chinese Medical Journal 2004;117(1):75-78
- CountryChina
- Language:English
-
Abstract:
BACKGROUNDUterine arterial embolization (UAE) is a safe and effective therapy for symptomatic uterine leiomyoma. This study was to assess the effectiveness and the feasibility of pingyangmycin-lipiodol emulsion (PLE) for the management of symptomatic uterine leiomyoma.
METHODSOne hundred consecutive patients (aged 21 - 53 years, with 38 in average) with symptomatic uterine leiomyoma underwent superselective UAE with PLE. Clinical symptoms of the patients (including menorrhagia, bulk-related symptoms, and postprocedure-related abdominal pain) and the changes in uterine volume and tumor size after the embolization were analyzed. The patients were followed up for 8 - 21 months (mean, 15 months).
RESULTSNinety-nine patients (99%, 99/100) were interviewed in their first menses circle after embolization, showing improvements in their abnormal bleeding and bulk-related symptoms to some extent. Imagiological results during follow-up showed a mean of 48% reduction in uterine volume at 6 months and a mean of 75% reduction in tumor size at 9 months. Eighty-three percent of the patients reported complete resolution of postprocedure pain within 7 days.
CONCLUSIONSPLE is effective in the management of uterine leiomyoma, having superiority in alleviating postprocedure-related pain.
