A new 3, 4-seco-lanostane triterpenoid from a marine-derived fungus Ascotricha sp. ZJ-M-5.
- Author:
Lei-Rui XIE
1
;
Dan-Yi LI
;
Pei-Le WANG
;
Hui-Ming HUA
;
Xin WU
;
Zhan-Lin LI
Author Information
1. Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
- Publication Type:Journal Article
- MeSH:
Antineoplastic Agents;
chemistry;
isolation & purification;
pharmacology;
Ascomycota;
chemistry;
Carbolines;
chemistry;
isolation & purification;
pharmacology;
Cell Line, Tumor;
Cell Proliferation;
drug effects;
Dipeptides;
chemistry;
isolation & purification;
pharmacology;
Drug Screening Assays, Antitumor;
Humans;
Lanosterol;
analogs & derivatives;
chemistry;
isolation & purification;
pharmacology;
Molecular Structure;
Peptides, Cyclic;
chemistry;
isolation & purification;
pharmacology
- From:
Acta Pharmaceutica Sinica
2013;48(1):89-93
- CountryChina
- Language:Chinese
-
Abstract:
To study the secondary metabolites of a marine-derived fungus Ascotricha sp. ZJ-M-5, several chromatographic methods including macroporous resin, silica gel, ODS and Sephadex LH-20 were used to isolate the compounds, and their structures were elucidated on the basis of physicochemical properties and spectroscopic methods. Ten compounds were obtained and identified as ascotrichic acid B (1), (3R)-6-hydroxymellein (2), beta-carboline (3), (22E, 24R)-ergosta-7, 22-diene-3beta, 5alpha, 6beta-triol (4), (22E, 24R)-ergosta-7, 22-diene-3beta, 5alpha, 6beta, 9alpha-tetraol (5), cyclo (Leu-Pro) (6), cyclo (Ile-Leu) (7), cyclo (Pro-Val) (8), cyclo (Pro-Gly) (9), and cyclo (Hpro-Ala) (10). Among them, compound 1 is a new 3, 4-seco-lanostane triterpenoid which has been isolated from the filamentous fungi for the first time, and compounds 2-10 are firstly isolated from Ascotricha genus.
