Research progress of transgenic Drosophila model of Alzheimer disease.
- Author:
Yan TAN
1
;
Yu-Bin JI
;
Jian ZHAO
Author Information
1. Research Center of Life and Environment Science, Harbin University of Commerce, Harbin 150076, China.
- Publication Type:Journal Article
- MeSH:
Alzheimer Disease;
etiology;
genetics;
metabolism;
Amyloid beta-Peptides;
metabolism;
Animals;
Animals, Genetically Modified;
genetics;
Disease Models, Animal;
Drosophila;
genetics;
Drug Evaluation, Preclinical;
Gene Transfer Techniques;
Humans;
Phosphorylation;
tau Proteins;
metabolism
- From:
Acta Pharmaceutica Sinica
2013;48(3):333-336
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer disease (AD) is a common neurodegenerative disease. Drosophila has been regard as one of the ideal models for Alzheimer because of its unique advantage on genetic manipulation. AD transgenic drosophila models not only help to elucidate the pathogenesis of Alzheimer disease, but also provide potential screening models for drugs to treat the disease. In this review, we summarize the recent research progress using AD transgenic drosophila.
