Design, synthesis, and PPARgamma agonistic activity of novel indenone derivatives.
- Author:
Li-Li QU
1
;
Yu-Heng MA
Author Information
1. School of Pharmacy, Baotou Medical College, Baotou 014040, China.
- Publication Type:Journal Article
- MeSH:
Drug Design;
Hypoglycemic Agents;
pharmacology;
Indenes;
chemical synthesis;
chemistry;
pharmacology;
Magnetic Resonance Spectroscopy;
Mass Spectrometry;
Molecular Structure;
PPAR gamma;
agonists;
Structure-Activity Relationship;
Thiazolidinediones;
pharmacology
- From:
Acta Pharmaceutica Sinica
2013;48(4):508-513
- CountryChina
- Language:Chinese
-
Abstract:
Agonists of peroxisome proliferator-activated receptor gamma (PPARgamma) are of interest as a treatment of type II diabetes, and indenone derivatives are a new class of non-TZD PPARgamma agonists. Based on existing indenone derivatives, a series of novel ones have been designed and synthesized. Meanwhile the structures have been comfirmed with 1H NMR and MS. Among them, 17b and 19 showed higher agonistic activities than rosiglitazone.
