Synthesis and bioactivity of the folate receptor targeted gamma-cyclodextrin-folate inclusion-coated CdSe/ZnS quantum dots.
- Author:
Mei-Xia ZHAO
1
;
Yang LI
;
Chao-Jie WANG
Author Information
1. Key Laboratory of Natural Medicine and Immune Engineering, Henan University, Kaifeng 475004, China. zhaomeixia2011@henu.edu.cn
- Publication Type:Journal Article
- MeSH:
Cadmium Compounds;
chemical synthesis;
chemistry;
metabolism;
toxicity;
Cell Survival;
drug effects;
Folate Receptor 1;
chemistry;
Folic Acid;
chemistry;
HeLa Cells;
Hep G2 Cells;
Humans;
Magnetic Resonance Spectroscopy;
Microscopy, Electron, Transmission;
Molecular Imaging;
methods;
Quantum Dots;
chemistry;
metabolism;
toxicity;
Selenium Compounds;
chemical synthesis;
chemistry;
metabolism;
toxicity;
Spectrophotometry, Ultraviolet;
Spectroscopy, Fourier Transform Infrared;
Sulfides;
chemical synthesis;
chemistry;
metabolism;
toxicity;
Zinc Compounds;
chemical synthesis;
chemistry;
metabolism;
toxicity;
gamma-Cyclodextrins;
chemistry
- From:
Acta Pharmaceutica Sinica
2013;48(4):566-572
- CountryChina
- Language:Chinese
-
Abstract:
The gamma-cyclodextrin-folate (gamma-CD/FA) inclusion-coated CdSe/ZnS quantum dots (QDs) with folate-receptor (FR) targeted were synthesized by simple and convenient sonochemical method. The products were studied using Fourier transform infrared (FTIR), proton nuclear magnetic resonance (1H NMR), utraviolet-visible spectrometry (UV-vis), fluorescence spectrum and transmission electron micrographs (TEM). The results showed that the gamma-CD/FA-coated CdSe/ZnS QDs not only have good monodispersity and smaller size, but also have good optical performance, such as higher quantum yield (QY) and a long fluorescence lifetime. The cytotoxicity experiments showed that the gamma-CD/FA-coated CdSe/ZnS QDs have lower cytotoxicity and could more effectively enter cancer cells with FR over-expression. The QDs with 4-5 nm in diameter were relatively easy to enter the cell and to be removed through kidneys, so it is more suitable for biomedical applications for bioprobes and bioimaging.
