Application of phosphates and phosphonates prodrugs in drug research and development.
- Author:
Xun JI
1
;
Jiang WANG
;
Lei ZHANG
;
Lin-Xiang ZHAO
;
Hua-Liang JIANG
;
Hong LIU
Author Information
1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Biological Availability;
Drug Design;
Drug Stability;
Humans;
Molecular Structure;
Organophosphonates;
chemical synthesis;
chemistry;
pharmacokinetics;
Phosphates;
chemical synthesis;
chemistry;
pharmacokinetics;
Prodrugs;
chemical synthesis;
chemistry;
classification;
pharmacokinetics;
Solubility;
Structure-Activity Relationship;
Tissue Distribution
- From:
Acta Pharmaceutica Sinica
2013;48(5):621-634
- CountryChina
- Language:Chinese
-
Abstract:
Based on the character of the molecular structure, the prodrugs of phosphates and phosphonates were divided into two categories. The first is the drug which contained the phosphate group, introducing protected groups to increase lipophilicity and improve bioavailability. The other one is the drug which had no phosphate group, introducing the phosphate group into molecules to enhance the solubility, regulate the distribution coefficient and enhance the drug-like property. This review focuses on the application of phosphates and phosphonates in drug research and development based on improvement of physico-chemical property, drug safety and the pharmacokinetics.
