Association of a SLC30A8 genetic variant with monotherapy of repaglinide and rosiglitazone effect in newly diagnosed type 2 diabetes patients in China.
- Author:
Feng JIANG
1
;
Qing LI
;
Cheng HU
;
Rong ZHANG
;
Cong Rong WANG
;
Wei Hui YU
;
Jing Yi LU
;
Shan Shan TANG
;
Yu Qian BAO
;
Kun San XIANG
;
Wei Ping JIA
Author Information
- Publication Type:Journal Article
- MeSH: Carbamates; therapeutic use; Cation Transport Proteins; genetics; China; Diabetes Mellitus, Type 2; drug therapy; genetics; Female; Gene Frequency; Humans; Hypoglycemic Agents; therapeutic use; Male; Middle Aged; Piperidines; therapeutic use; Polymorphism, Single Nucleotide; Thiazolidinediones; therapeutic use; Zinc Transporter 8
- From: Biomedical and Environmental Sciences 2012;25(1):23-29
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo investigate a potential relationship between Solute carrier family 30 (zinc transporter) member 8 (SLC30A8) rs13266634 variant and efficacy of rosiglitazone or repaglinide in treating newly diagnosed Chinese type 2 diabetes patients.
METHODSA total of 209 diabetic patients without any antihyperglycemic history were recruited and treated with repaglinide or rosiglitazone randomly for 48 weeks (104 and 105 patients, respectively). Anthropometric measurements and clinical laboratory tests were carried out before and after the treatment. An non-synonymous variant rs13266634 was genotyped by matrix-assisted laser desorption ionization-time of flight mass spectroscopy.
RESULTSNinety-one patients in repaglinide group and ninety-three patients in rosiglitazone group completed the study. Δ value of homeostasis model assessment of beta cell function (HOMA-B) and Δ value of fasting proinsulin levels were statistically significant between three genotype groups (P=0.0149 and 0.0246, respectively) after rosiglitazone treatment. However, no genotype association was observed in the repaglinide or rosiglitazone group with other parameters.
CONCLUSIONThe SLC30A8 variant was associated with the efficacy of insulin sensitizer monotherapy on insulin secretion in patients with newly diagnosed type 2 diabetes mellitus in Shanghai, China.
