Liver enzymes concentrations are closely related to prediabetes: findings of the Shanghai Diabetes Study II (SHDS II).
- Author:
Fei GAO
1
;
Jie Min PAN
;
Xu Hong HOU
;
Qi Chen FANG
;
Hui Juan LU
;
Jun Ling TANG
;
Hui Lin GU
;
Zhi Jian PAN
;
You Hua YAO
;
Wei Zhen SHEN
;
Wei Ping JIA
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Alanine Transaminase; blood; Anthropometry; China; Female; Glycated Hemoglobin A; metabolism; Humans; Lipid Metabolism; Liver; enzymology; Male; Middle Aged; Prediabetic State; blood; enzymology; Young Adult; gamma-Glutamyltransferase; blood
- From: Biomedical and Environmental Sciences 2012;25(1):30-37
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo investigate the relationship of liver enzymes with hyperglycemia in a large population in Shanghai and identify the association between liver enzymes and insulin resistance.
METHODSA total of 3 756 participants were enrolled. Each participant underwent an oral glucose tolerance test and completed a questionnaire. Anthropometric indices were recorded and serum samples were collected for measurement.
RESULTSLiver enzymes concentrations were independently associated with i-IGT, IFG+IGT, and diabetes. With the increase of ALT and GGT concentrations, ORs for i-IGT, IFG+IGT, and diabetes increased gradually. By comparing patients in the highest quartile of GGT concentrations or ALT concentrations with those in the lowest quartile (Q1), ORs for i-IGT, IFG+IGT, or diabetes was significant after adjustment. Both ALT and GGT concentrations were linearly correlated with HOMA-IR and independently associated with HOMA-IR [ALT OR (95% CI): 2.56 (1.51-4.34) P=0.00; GGT OR (95% CI): 2.66 (1.53-4.65) P=0.00].
CONCLUSIONSerum ALT and GGT concentrations were closely related to pre-diabetes and diabetes in the Shanghai population and positively associated with insulin resistance.
