The effect of transmission electron microscopy on diagnosis of acute myeloid leukemia.
- Author:
Shu-xu DONG
1
;
Shi-xuan ZHAO
;
Jin-hua LIU
;
Ying-chang MI
;
Xiao-fan ZHU
;
Yu-mei CHEN
;
Zhi-jian XIAO
;
Yong-xin RU
;
Jian-xiang WANG
Author Information
- Publication Type:Journal Article
- MeSH: Humans; Leukemia, Myeloid, Acute; classification; diagnosis; Microscopy, Electron, Transmission; Retrospective Studies
- From: Chinese Journal of Hematology 2013;34(3):205-207
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze coincidence rate of acute myeloid leukemia (AML) sub-typing between transmission electron microscopy (TEM) and clinical discharge diagnosis.
METHODSReviewing sub-typing results of TEM, light microscopy, flow cytometric analyzing, molecular biological detection and karyotype in 793 AML cases, comparing their coincidence rates with discharge diagnosis to reveal advantages of AML sub-typing by TEM.
RESULTSGeneral coincidence rates of TEM, light microscopy, flow cytometric analyzing, molecular biological detection and karyotype on AML sub-typing were 63%, 59%, 52%, 47%, 26% and 23% respectively, and clinical coincidence rates of TEM on M1, M2a, M4 and M5, M6, M7, t (8; 21) and t (15; 17) were 39%, 34%, 17%, 74%, 50%, 73%, 87% and 89% respectively.
CONCLUSIONTEM has a higher coincidence rate in general AML sub-typing, especially strong screenings on t (15; 17), t (8; 21), M7, M5 and M6, but lower coincidence rates on M1, M2a and M4 sub-typing than other methods.
