Acute leukemia child with ocular Kaposi's sarcoma after hematopoietic stem cell transplantation: a case report and literatures review.
- VernacularTitle:白血病患儿造血干细胞移植后发生眼Kaposi肉瘤一例报告附文献复习
- Author:
Hai-xia GUO
1
;
Ke HUANG
;
Dun-hua ZHOU
;
Lin WANG
;
Jian-hui XIAO
;
Wen-jun WENG
;
Jian-pei FANG
Author Information
- Publication Type:Case Reports
- MeSH: Adolescent; Eye Neoplasms; Hematopoietic Stem Cell Transplantation; Humans; Male; Postoperative Complications; Precursor Cell Lymphoblastic Leukemia-Lymphoma; therapy; Sarcoma, Kaposi
- From: Chinese Journal of Hematology 2013;34(5):445-448
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo summarize clinical features of eye Kaposis' sarcoma ( KS ) in leukemia child after peripheral blood stem cell transplantation (PBSCT).
METHODSOne 13 years-old child with acute lymphoblastic leukemia (ALL) and negative HIV test who developed KS restricted in right conjunctiva, cornea and sclera after successful allogeneic PBSCT was reviewed retrospectively.
RESULTSThe child suffered from T cell type ALL. He received immunosuppressive treatment after PBSCT, and had once extensive herpes zoster restricted in skin. Seven months after PBSCT, he had blurred vision with right eye and slowly neoplasm formed in cornea and conjunctiva. Pathological examination confirmed KS with changes like capillary hemangioma, atypical fusiform cell, typical immunochemistry and positive immunofluorescent result of HHV8. He received excision of lump of cornea, conjunctiva, sclera and transplantation of cornea and sclera. Antiviral therapy was given together with anti-infection, prevention of cornea rejection and biotherapy. He kept right eye and hand-move eyesight, survived without GVHD or recurrence of ALL and KS.
CONCLUSIONThis was the first ocular KS case in ALL child after PBSCT, without correlation with HIV infection. Complete excision combined with biotherapy was safe and effective for single ocular lesions.