Attenuation of cardiac ischemia/reperfusion injury by transient low hydroperoxide pretreatment in rat.
- Author:
Run-He FENG
1
;
Jin-Cai ZHANG
;
Xiao-Qian LI
;
Hai-Li SUN
;
Bin LIU
;
Yun-Zhen ZHAO
;
Xiang-Dong TANG
;
Jing LI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Hydrogen Peroxide; administration & dosage; Ischemic Preconditioning; methods; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury; prevention & control
- From: Chinese Journal of Applied Physiology 2013;29(3):247-250
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate how transient low dose of hydroperoxide pretreatment prevents cardiac ischemia/reperfusion injury.
METHODSSD rats were divided into 4 groups: sham operation (Sham), standard ischemia/reperfusion (I/R), ischemic preconditioning (IPC) and IR preceded by low H2O2 treatment. Cardiac function and injury parameter were compared among groups.
RESULTSIPC protected reperfusion injury and improved cardiac function. Low H2O2 treatment played a role in cardioprotection similar to IPC. Low H2O2 was indeed generated in the early phase of simulated ischemia and attenuated cytochrome c release induced by high Ca2+ in isolated mitochondria.
CONCLUSIONLow H2O2 plays a critical role in cardioprotection probably by inhibiting mitochondrial permeability transition.
