Effects of retinol acid and triiodothyronine on alleviating the impairment of cognitive function by sleep deprivation.
- Author:
Na ZHANG
1
;
Qiang MA
;
Xue-Wei CHEN
;
Chuan-Xiang XU
;
Gai-Hong AN
;
Bo CUI
;
Xiao-Jun SHE
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cognition; drug effects; Dentate Gyrus; metabolism; Long-Term Potentiation; Male; Neurogranin; metabolism; Rats; Rats, Wistar; Sleep Deprivation; metabolism; psychology; Triiodothyronine; pharmacology; Vitamin A; pharmacology
- From: Chinese Journal of Applied Physiology 2013;29(4):294-300
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the effects of retinol acid (RA) and triiodothyronine (T3) on alleviating the impairment of cognitive function by sleep deprivation (SD).
METHODSMale Wistar rats were divided into 4 groups: control group (C group), sleep deprivation group (SD group), sleep deprivation + RA group (SD + RA group) and sleep deprivation + T3 group (SD + T3 group). Open field test (OFT) was used to observe the nervous behavior of the rats after SD and electrophysiological brain stereotactic method was used to test long-term potentiation (LTP) in dentate gyrus (DG) of the rats. Ng protein expression was determined by Western blot.
RESULTSCompared with the SD group, the number of crossing in OFT, the changes of amplitude of population spike (PS) and the expression of Ng protein in hippocampus were higher significantly in the SD + RA and SD + T3 groups. All of these had not significant difference comparing with the C group.
CONCLUSIONRA and T3 may alleviate the restrain state of neural system after SD by augmenting the expression of Ng protein in hippocampus.
