No relation between ACE-I/D polymorphism and high altitude pulmonary edema in the Han Chinese.
- Author:
Ying-Zhong YANG
;
Ya-Ping WANG
;
Wei GUAN
;
Yang DU
;
Qin GA
;
Ri-Li GE
- Publication Type:Journal Article
- MeSH: Alleles; Altitude; Asian Continental Ancestry Group; genetics; Case-Control Studies; Gene Frequency; Genotype; Humans; Peptidyl-Dipeptidase A; genetics; Polymorphism, Genetic; Pulmonary Edema; genetics
- From: Chinese Journal of Applied Physiology 2013;29(6):508-517
- CountryChina
- Language:English
-
Abstract:
OBJECTIVESTo explore whether the angiotensin I -converting enzyme (ACE) I/D (insertion/ deletion) polymorphism is associated with the susceptibility to high altitude pulmonary edema (HAPE) in the Han Chinese.
METHODSOne hundred and forty-seven HAPE-p (HAPE patients) and 193 HAPE-r (HAPE resistants) were enrolled from the Yushu earthquake reconstruction workers in Qinghai province where the altitude is over 3 500 m above sea level. Blood samples were collected from each of the HAPE-p and HAPE-r groups. Information about physiological phenotypes was obtained via fieldwork investigation. The ACE-I/D polymorphism in HAPE-p and HAPE-r was detected by polymerase chain reaction (PCR).
RESULTSThe SaO2 was significantly lower while HR was significantly higher in HAPE-p group than those in HAPE-r group. The genotype frequencies of ACE-I/D for II, ID, DD in HAPE-r and HAPE-p groups were 0.430, 0.446, 0.124 and 0.435, 0.469, 0.095, respectively, the allelic frequencies of I and D were 0.650, 0.350 and 0.670, 0.330, respectively. The OR of ID, DD and D alleles relative to II for HAPE was 0.961 (0.610-1.514), 1.322 (0.634-2.758) and 1.080 (0.783-1.489). There was no significant difference of the genotypic and the allelic frequencies in ACE-I/D polymorphism between HAPE-p and HAPE-r groups.
CONCLUSIONSThere is no relation between ACE-I/D polymorphism and HAPE in the Han Chinese.