Effect of Xinmaitong capsule on serum matrix metalloproteinases-9, high sensitive C-reactive protein levels in patients with acute coronary syndrome.
- Author:
Jun MENG
1
;
Jian QIN
;
Yun MA
;
Hui-Ma SUN
;
Chu-Fan LUO
;
Rui-Xiang QIU
Author Information
- Publication Type:Journal Article
- MeSH: Acute Coronary Syndrome; blood; drug therapy; Aged; C-Reactive Protein; metabolism; Capsules; Cholesterol; blood; Cholesterol, HDL; blood; Cholesterol, LDL; blood; Drug Combinations; Drugs, Chinese Herbal; isolation & purification; therapeutic use; Female; Humans; Male; Matrix Metalloproteinase 9; blood; Middle Aged; Phytotherapy; Plants, Medicinal; chemistry; Triglycerides; blood
- From: China Journal of Chinese Materia Medica 2007;32(9):850-852
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the influence of Xinmaitong capsule (XMT) on serum matrix metalloproteinases-9, high sensitive C-reactive protein levels in patients with acute coronary syndrome.
METHOD63 cases were divided by randomized, contrastive assigned to XMT group (n = 31) and control group (n = 32). The serum levels of MMP-9 and hs-CRP before and after treatment in 12 weeks were detected.
RESULTAfter treatment, the serum levels of MMP-9 in control group had no changed and the levels of hs-CRP reduced. The serum levels of MMP-9 and hs-CRP in XMT group had significantly decreased. The serum levels of MMP-9 and hs-CRP had positive correlation, but had no correlation to levels of serum lipids.
CONCLUSIONXMT decreased breakdown of matrix collagen, and inflammatory reaction in the patients of ACS, which may have effect on plaque stabilization.
