Studies on protective effects of Niuhuang Shangqing pills on cerebral ischemia.
- Author:
Lei ZHANG
1
;
Yong ZHAO
;
Lei ZHANG
;
Ting LIU
;
Chun-Ying LI
;
Ran JIN
;
Lei ZHOU
;
Jian-Rong LI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Blood Viscosity; drug effects; Brain; drug effects; metabolism; pathology; Brain Infarction; etiology; pathology; prevention & control; Brain Ischemia; blood; complications; prevention & control; Catalase; metabolism; Drug Combinations; Drugs, Chinese Herbal; isolation & purification; pharmacology; therapeutic use; Glutathione Peroxidase; metabolism; Male; Malondialdehyde; metabolism; Medicine, Chinese Traditional; Neuroprotective Agents; isolation & purification; therapeutic use; Phytotherapy; Plants, Medicinal; chemistry; Random Allocation; Rats; Rats, Sprague-Dawley
- From: China Journal of Chinese Materia Medica 2007;32(10):943-948
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo discuss the protective effect of Niuhuang Shangqing pills (NSP) on the experimental cerebral ischemia and the influence of blood rheology in animals.
METHODUsing the middle cerebral artery occlusion (MCAO), bilateral common carotid artery ligation and lipopolysaccharide (LPS) in combination with carrogeenin (Ca)-induced stagnation of blood model rats, we investigated the influence of NSP on the physical sign indexes, brain infarct size and the water content, the content of lactate(LD), glutathione peroxidase (GPx), catalase (CAT), malondialdehyde (MDA) and the blood rheology.
RESULTThe 3.00, 1.50 g x kg(-1) dosage groups of NSP decreased the neurosigns indexes, significantly reduced the brain infarct areas in MCAO rats, decreased the brain water content, increased the activities of GPx and CAT, decreased the content of LD and MDA in bilateral common carotid artery ligation rats. They improved the blood rheology in lipopolysaccharide (LPS) in combination with carrogeenin (Ca)-induced stagnation of blood model rats.
CONCLUSIONNSP has the function of protective effect on experimental experimental cerebral ischemia.
