Effects of alligator Zhikegao on relieving cough dispelling phlegm and anti-inflammation.
- Author:
Dong-Hui XU
1
;
Zhao-Zhang LUO
;
Xue-Ting MEI
;
Hai-Ping MA
;
Jun-Ling ZENG
;
Shi-Bo XU
Author Information
- Publication Type:Journal Article
- MeSH: Alligators and Crocodiles; Animals; Anti-Inflammatory Agents, Non-Steroidal; isolation & purification; therapeutic use; Antitussive Agents; isolation & purification; therapeutic use; Cough; drug therapy; Drug Combinations; Drugs, Chinese Herbal; isolation & purification; therapeutic use; Ear Diseases; drug therapy; Edema; drug therapy; Expectorants; isolation & purification; therapeutic use; Female; Glycosaminoglycans; isolation & purification; therapeutic use; Granuloma; drug therapy; Male; Materia Medica; isolation & purification; therapeutic use; Medicine, Chinese Traditional; Mice; Plants, Medicinal; chemistry; Random Allocation; Rats; Rats, Sprague-Dawley
- From: China Journal of Chinese Materia Medica 2007;32(10):961-965
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo research the effects of Alligator Zhikegao on relieving cough, dispelling phlegm and anti-inflammation.
METHODThe coughing tests in mice, the phenol red secreting tests in mice, ear edema tests in mice,and paw edema tests and subcutaneous cotton ball granuloma in rats were adopted for observing the related pharmacological effects of Alligator Zhikegao.
RESULTAlligator Zhikegao could obviously prolong the latent period and decrease the times of mouse coughing, and remarkably inhibit the mouse ear edema (P < 0.001), the rat paw edema and the hyperplasia of subcutaneous cotton ball granuloma in rats. Alligator Zhikegao 11.70 g x kg(-1) could significant improve the carbonic clearances of macrophages (P <0.05) and the hemolysin level in serum (P <0.01).
CONCLUSIONAlligator Zhikegao has significant effects on relieving cough, dispelling phlegm, anti-inflammation and immunological regulation.
