Study on drug release in vitro and rat intestinal absorption of resveratrol nanoliposomes.
- Author:
Xin-chun WANG
1
;
Shi-xiang HOU
;
Wen LI
;
Xiao-ying LI
;
Ya-wei ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Administration, Oral; Animals; Delayed-Action Preparations; Drug Compounding; Fallopia japonica; chemistry; Ileum; metabolism; Intestinal Absorption; Liposomes; Male; Nanoparticles; Particle Size; Plants, Medicinal; chemistry; Rats; Rats, Wistar; Stilbenes; administration & dosage; isolation & purification; pharmacokinetics
- From: China Journal of Chinese Materia Medica 2007;32(11):1084-1088
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the release feature of Res-nanoliposomes in vitro and clarify the difference in absorption of Res-nanoliposomes from varied intestinal segments and the absorptive mechanism in vivo.
METHODDialytic method was used to determine resveratrol release rate of Res-nanoliposomes in vitro. An in situ rat perfusion method was used to investigate the intestinal absorption of Res-nanoliposomes.
RESULTResveratrol release from nanoliposomes in vitro fitted the log-normal distribution equation and had a property of sustained release. Compared with other intestinal segments, significantly high percentage of Res-nanoliposomes was absorbed in ileum (P < 0.001). The absorption rate constants (ka) of Res-nanoliposomes in intestine were not significantly different.
CONCLUSIONRes-nanoliposomes could sustain to release drug in vitro. The absorption was a first-order process with the passive diffusion mechanism. The Res-nanoliposomes could promote the absorption of Res in rat small intestine.
