Effects of allicin on changes of hemorheology in focal cerebral ischemia-reperfusion injury.
- Author:
Chun-yan LI
1
;
Xiao-song CHENG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Blood Viscosity; drug effects; Garlic; chemistry; Infarction, Middle Cerebral Artery; complications; Male; Neuroprotective Agents; isolation & purification; pharmacology; Plants, Medicinal; chemistry; Random Allocation; Rats; Rats, Wistar; Reperfusion Injury; blood; etiology; pathology; Sulfinic Acids; isolation & purification; pharmacology
- From: China Journal of Chinese Materia Medica 2007;32(13):1314-1317
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the effects of allicin on the changes of hemorheology in focal cerebral ischemia-reperfusion injury in rats.
METHODMiddle cerebral artery occlusion (MCAO) was used to make focal cerebral ischemia-reperfusion model by intravascular nylon filament occlusion. The protective effects of allicin at different doses were evaluated by investigating neurological function score, infarction volume and water content of brain. The changes of blood rheology were detected.
RESULTCompared with model group, allicin (15, 25 mg x kg(-1)) increased the neurological function score and decreased the water content and infarction volume of brain in rats. Allicin (15, 25 mg x kg(-1)) inhibited the increasing of the blood viscosity, high shear rate reduced viscosity, high shear relative reduced viscosity and low shear relative reduced viscosity.
CONCLUSIONAllicin has protective effects on cerebral ischemia-reperfusion injuries. The mechanism may be related to inhibit the increasing of hemorheology.
