Roles of potassium channel in effects of resveratrol on isolated myocardial contractility and heart rate research in guinea pig.
- Author:
Gui-ying WANG
1
;
Cui-miao SONG
;
Li-nan ZHANG
;
Qian LI
;
Hua YUE
;
Jing-kun FENG
;
Na WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Barium Compounds; pharmacology; Cardiotonic Agents; administration & dosage; isolation & purification; pharmacology; Chlorides; pharmacology; Dose-Response Relationship, Drug; Female; Glyburide; pharmacology; Guinea Pigs; Heart Rate; drug effects; In Vitro Techniques; KATP Channels; antagonists & inhibitors; Male; Myocardial Contraction; drug effects; Plants, Medicinal; chemistry; Potassium Channel Blockers; pharmacology; Potassium Channels, Calcium-Activated; antagonists & inhibitors; Potassium Channels, Inwardly Rectifying; antagonists & inhibitors; Stilbenes; administration & dosage; isolation & purification; pharmacology; Tetraethylammonium; pharmacology
- From: China Journal of Chinese Materia Medica 2007;32(13):1317-1319
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effects of resvaratrol derivatives on spontaneous HR and CF of isolated guinea pig atrium.
METHODThe dose-effect curve of resvaratrol was observed. The possible mechanism of potassium channels responsible for changes of CF and HR after administering with resvaratrol was measured.
RESULTResvaratrol reduced the spontaneous HR and weakened the CF in a dose-dependent manner ranging from 10(-6) to 3 x 10(-4) mol x L(-1) (P < 0.05). As compared with Res group, the effects were partly blocked by Gli (P < 0.05) and TEA (P < 0.01), but not blocked by 4-AP, BaCl2, Atropine.
CONCLUSIONResvaratrol can induce negative chronotropic action and negative (inotropic action. The mechanism(s) may relate to the opening of K(ATP) and Kc(Ca).
