Role of miR-145 in erectile dysfunction in diabetic rats.
- Author:
An-yang WEI
1
;
Yong YANG
;
Shu-hua HE
;
Xin-gui LUO
;
Tao ZHANG
;
Yang LIU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Diabetes Mellitus, Experimental; complications; metabolism; physiopathology; Erectile Dysfunction; etiology; metabolism; physiopathology; Male; MicroRNAs; genetics; metabolism; Muscle, Smooth; metabolism; Penile Erection; Rats; Rats, Sprague-Dawley
- From: Journal of Southern Medical University 2011;31(6):1051-1054
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the role of miR-145 in the corpus cavernosum smooth muscle tissue in the pathogenesis of erectile dysfunction (ED) in diabetic rats.
METHODSThe total RNA was extracted from the corpus cavernosum of a diabetic rat model with ED, diabetic rats with normal erectile function and normal rats, and the expression levels of miR145 were compared between the groups.
RESULTSThe expression of miR-145 was decreased in the corpus cavernosum of diabetic rats with ED.
CONCLUSIONDiabetes mellitus can cause ED in rats, in which process decreased expression of miR145 in the corpus cavernosum may play a role.
