Investigation of mRNA expression of collagen genes in oral squamous cell carcinoma and paired normal tissue.
- Author:
Xiao-zhi LÜ
1
;
Wan-tao CHEN
;
Chen-ping ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; metabolism; Collagen; genetics; metabolism; Collagen Type I; genetics; metabolism; Female; Humans; Male; Middle Aged; Mouth Neoplasms; metabolism; RNA, Messenger; genetics; metabolism; Young Adult
- From: Journal of Southern Medical University 2011;31(7):1197-1199
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the mRNA expression of collagen genes in oral squamous cell carcinoma (OSCC) and paired normal oral mucosal tissue.
METHODSThe differential mRNA expressions of collagen genes between 30 OSCC tissues and the paired normal oral mucosal tissues were detected by RT-PCR.
RESULTThe relative expression level of COL1A1 mRNA in the 30 cancerous tissues was up-regulated by 2.78 folds as compared with its expression in the paired normal samples, suggesting its significant overexpression in OSCC (P<0.001). The expression levels of COL1A2, COL4A1, COL4A2, and COL5A2 mRNA in the cancerous tissues were up-regulated by 1.07, 1.15, 1.27, and 1.16 folds compared to those in paired normal samples (P>0.05).
CONCLUSIONCOL1A1 mRNA overexpression may play an important role in the carcinogenesis of OSCC and can be a potential molecular marker of OSCC.
