Correlation between serum growth differentiation factor-15 and TIMI risk scores in patients with unstable angina pectoris.
- Author:
Ming-yao DENG
1
;
Guo-ping WU
;
Xu-xia FENG
;
Jiang-bin LUO
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Angina, Unstable; blood; drug therapy; Female; Growth Differentiation Factor 15; blood; Humans; Male; Middle Aged; Risk Assessment; Severity of Illness Index; Thrombolytic Therapy; adverse effects
- From: Journal of Southern Medical University 2011;31(7):1277-1278
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the correlation between serum levels of growth differentiation factor-15 (GDF-15) and Thrombolysis in Myocardial Infarction (TIMI) risk scores in patients with unstable angina pectoris (UA).
METHODSThe serum levels of GDF-15 in 97 patients with UA and 30 healthy volunteers were measured using enzyme-linked immunosorbent assay (ELISA) and compared between 3 patient groups with different TIMI scores to analyze relationship between serum GDF-15 levels and TIMI risk scores.
RESULTSThe serum levels of GDF-15 in UA patients were significantly higher than those in the healthy volunteers (P<0.01). GDF-15 levels also differed significantly between patients with different TIMI scores (P<0.01), and showed a significant positive correlation to TIMI risk scores.
CONCLUSIONSerum levels of GDF-15 can be used as an index for evaluating the severity of UA.
