Endometrial microvessel density for assessing endometrial receptivity during the peri-implantation period.
- Author:
Qiu-hua LI
1
;
Min YU
;
Lei-ning CHEN
;
Hong LI
;
Chen LUO
;
Si-mei CHEN
;
Song QUAN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Embryo Implantation; physiology; Embryo Transfer; Endometrium; blood supply; physiology; Female; Fertilization in Vitro; Humans; Infertility, Female; diagnostic imaging; physiopathology; therapy; Microvessels; ultrastructure; Retrospective Studies; Ultrasonography
- From: Journal of Southern Medical University 2011;31(8):1365-1368
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the value of endometrial microvessel density (MVD) in assessing the endometrial receptivity during the peri-implantation period.
METHODSA total of 104 patients undergoing in vitro fertilization and embryo transfer (IVF-ET) treatment were analyzed retrospectively. The subjects were divided into clinical pregnancy group (50 cases) and nonpregnant group (54 cases) according to the IVF-ET outcome. Endometrial tissues were collected 7 days after the natural ovulation prior to IVF-ET for measurement of the endometrial MVD using electron microscopy, which was analyzed in relation to the clinical outcome of the treatment.
RESULTSThe endometrial MVD was significantly higher in the clinical pregnancy group than in the nonpregnant group [(4.12∓1.84)% vs (3.46∓1.26)%, t=-2.127, P=0.036). ROC curve analysis showed that the MVD had an area under the curve slightly over 0.5 (0.598) for predicting clinical pregnancy, suggesting a poor specificity in predicting the clinical outcome of the treatment.
CONCLUSIONIn IVF-ET cycles, the endometrial MVD during the peri-implantation period is helpful for assessing the endometrial receptivity, but the specificity remains low.
