Expressions of OCT4 and CD133 and their correlation in colonic cancer.
- Author:
Wen-sheng CHEN
1
;
Lei MA
;
Xiao-ye HU
;
Xiao-yan LIU
;
Chuan JIN
;
Zhi-biao LI
;
Wei-dong LI
Author Information
- Publication Type:Journal Article
- MeSH: AC133 Antigen; Adenocarcinoma; metabolism; surgery; Adult; Aged; Antigens, CD; metabolism; Colonic Neoplasms; metabolism; surgery; Female; Glycoproteins; metabolism; Humans; Immunochemistry; Male; Middle Aged; Octamer Transcription Factor-3; metabolism; Peptides; metabolism; Up-Regulation; Young Adult
- From: Journal of Southern Medical University 2011;31(8):1434-1436
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expressions of Oct4 and CD133 and their correlation in colonic cancer.
METHODSThe expression of Oct4 and CD133 were detected by immunohistochemistry in 30 colon cancer specimens and the paired adjacent tissues.
RESULTSThe positivity rates of Oct4 and CD133 expression were 83.3% (25/30) and 73.3% (22/30) in colonic cancer tissue, respectively, and their expressions were positively correlated (r=0.586, P<0.05). The matched adjacent tissues showed significantly lower levels of Oct4 and CD133 expressions (P<0.01).
CONCLUSIONThe expressions of Oct4 and CD133 are upregulated in colonic cancer compared with those in the adjacent tissues and show a positive correlation. Oct4 and CD133 may play an important role in the development of colon cancer.
