Expression and its significance of Cyclin D1 in oral squamous cell carcinoma.
- Author:
Jin-song XING
1
;
Pei-rong SHI
;
Xian-jiu CHEN
;
Dong-ning HE
;
Li-hua LI
;
Xin-rong NAN
Author Information
- Publication Type:Journal Article
- MeSH: Carcinoma, Squamous Cell; Cyclin D1; Female; Humans; Immunohistochemistry; Lymphatic Metastasis; Mouth Mucosa; Mouth Neoplasms; Prognosis
- From: West China Journal of Stomatology 2011;29(3):299-305
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression and significance of Cyclin D1 in oral squamous cell ma (OSCC).
METHODSA immunohistochemistry method, Envosion, was employed to test the manifesting Cyclin D1 in pathological slices of 50 OSCC cases and 10 normal cases, and the results was treated with statistical lysis.
RESULTSIn 50 OSCC cases, Cyclin D1 mainly manifested in karyon, and a little in cytoplasm. manifesting rates of Cyclin D1 in the samples was 80.0%, which was significantly higher than the manifesting of 20.0% in normal oral mucous membrane (P < 0.01). The manifestation of Cyclin D1 was correlated with rent pathological grades, clinical phases and lymph node metastasis (P < 0.05).
CONCLUSIONThe abnormal tation of Cyclin D1 is closely related with the occurrence and development of OSCC. Therefore, it can subsidiary index for OSCC treatment and prognosis.
