Efficacy of shenqi fuzheng injection combined with chemotherapy in treatment of acute leukemia and its effect on T-lymphocyte subsets, serum IFN-gamma, IL-10 and IL-2.
- Author:
Ying-Fei WEI
1
;
Su-Yun WANG
;
Li-Li REN
Author Information
- Publication Type:Clinical Trial
- MeSH: Adolescent; Adult; Aged; Antineoplastic Agents, Phytogenic; therapeutic use; Antineoplastic Combined Chemotherapy Protocols; therapeutic use; Drug Therapy, Combination; Drugs, Chinese Herbal; therapeutic use; Female; Humans; Interferon-gamma; blood; Interleukin-10; blood; Interleukin-2; blood; Leukemia, Myeloid, Acute; drug therapy; immunology; Male; Middle Aged; Phytotherapy; Precursor Cell Lymphoblastic Leukemia-Lymphoma; drug therapy; immunology; T-Lymphocyte Subsets; immunology
- From: Chinese Journal of Integrated Traditional and Western Medicine 2005;25(4):303-306
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the clinical efficacy of Shenqi Fuzheng Injection (SFI) combined with chemotherapy in treatment of patients with acute leukemia and its effect on the levels of T-lymphocyte subsets (CD4, CD8, CD4/CD8) and serum interferon-gamma(IFN-gamma), interleukin-10 (IL-10) and IL-2.
METHODSSixty-five patients with initial treating acute leukemia were randomly divided into 2 groups, the SFI group (n = 32) treated with SFI plus chemotherapy (CT), the control group (n = 33) treated with CT only. The remission rate, changes of peripheral mature neutrophilic granulocyte (PMNG) count, T-lymphocyte subsets, serum IL-10 and IL-2 before and after treatment were determined.
RESULTSThe remission rate in the two groups showed no obvious difference (P > 0.05). After CT for the 1st, 2nd and 3rd weeks, the PMNG count decreased in both groups, showing significant difference as compared with that before CT (P < 0.01 or P < 0.05). The PMNG count at the end of the 3rd and 4th week of CT remounted to higher than that at 1st and 2nd week, and the increment in the SFI group was significantly higher than that in the control group (P < 0.05). The levels of CD4, CD4 /CD8, IFN-gamma and IL-2 all increased in the two groups after treatment (P < 0.05, P < 0.01), however, that of IL-10 was significantly decreased (P < 0.01). The difference between the two groups in these criteria after treatment was also significant (P < 0.05).
CONCLUSIONSFI can improve and regulate the immune function of the patients with acute leukemia undergoing CT, it could promote bone marrow cells proliferation and enhance the efficacy.
